p53 isoforms can regulate p53 transcriptional activity
نویسندگان
چکیده
منابع مشابه
p53 isoforms change p53 paradigm
Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called p53 does not exist as a single protein, but is in fact a group of p53 protein isoforms whose expression can be manipulated to control the cellular response to treatment.
متن کاملp53 Pathways to Simulate the p53 Transcriptional Activity
We have conducted some simulations of biological pathways with hybrid functional Petri net (HFPN) after careful reading of papers and developed a powerful simulation tool “Cell Illustrator [5]” (CI) for representing biological pathways with HFPN. In this study, by using CI, we constructed pathway of CDK-dependent phosphorylation pathway and ARF-dependent pathway, to observe the effect of the ph...
متن کاملSimian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.
A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated transcription either directly through protein-protein association or indirectly through interaction w...
متن کاملTranscriptional regulation by p53.
Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal. Arguably p53's most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell's RNA polymerase II (RNAP II)-transcribed genes, and indirectly regulates...
متن کاملRole of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity.
Tubular damage by cisplatin leads to acute renal failure, which limits its use in cancer therapy. In tubular cells, a primary target for cisplatin is presumably the genomic DNA. However, the pathway relaying the signals of DNA damage to tubular cell death is unclear. In response to DNA damage, the tumor suppressor gene p53 is induced and is implicated in subsequent DNA repair and cell death by ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2005
ISSN: 0890-9369
DOI: 10.1101/gad.1339905